Possible uses of the Pharmaceutically-accepted Orotic Acid

Intuitively, it seems sensible to get the highest melting point derived it would be sensible to derivatize with the highest melting point derivatizing agent. Although there is no solid basis for such a prediction, there are some extended the likelihood that this is so. The derivative financial instrument will share some partial structure with the derivatizing agent, and if the functions of the agent contribute significantly to the high melting point and these features are preserved in the derivative's structure, some of the high melting point characteristic could have been foreseen, must be kept.

Highest melting point pharmaceutical salt former for reaction with basic substances is orotic acid.Its melting point is around 325 c. Its structure contains several hydrogen bond donors and acceptors that probably contributes character melting point and these hydrogen-bonding sites preserved in pharmaceutical salt formed.

Despite this used orotic acid salts rarely.

Alkali salts of orotic acid is poorly soluble. Orotic acid is also poorly soluble in water.Thus, sodium salts precipitated by adding a solution of N, N-dimethylethanol salt of orotic acid in 80% aqueous ethanol.This can be tried as a method to remove an alkali salt from an alcoholic solution of an organic compound. The alkali cation as an alkaline salt would be precipitated with orotic acid.The remaining orotic acid would also be the essential insoluble. N, N-dimethylethanol would be back in the solution, but this could be removed by extraction with a neutral organic solvent.

Orotic acid or salt orotic acid may be expected to form a complex with triphenyl Phosphine oxide, which is a good hydrogen bond Orotic acid has recipient. a imide NH, which is a good hydrogen bond donor.

Orotic acid can be a good substance to neutralize an aqueous base, since both alkaline salt and the free acid is mainly insoluble.

Exceptional solubility properties of orotic and salts metal makes it worth remembering when you try to isolate the organic bases, especially because, when it is acceptable, pharmaceutically, trace residues are not overly critical.

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